| 2026 | Bob and David Climb Machu Picchu | Self | Film |
| 2026 | David Cross: The End of the Beginning of the End | | Film |
| 2026 | David Cross: The End of the Beginning of the End | Director | Film |
| 2025 | Oh, Hi! | Steve | Film |
| 2023 | The Elephant 6 Recording Co. | Self | Film |
| 2023 | You Hurt My Feelings | Jonathan | Film |
| 2020 | Beastie Boys Story | Self | Film |
| 2020 | Time Warp Vol. 1: Midnight Madness | Self | Film |
| 2018 | Next Gen | Dr. Tanner Rice / Q-Bots (voice) | Film |
| 2017 | The Post | Howard Simons | Film |
| 2016 | Kung Fu Panda 3 | Crane (voice) | Film |
| 2015 | Pitch Perfect 2 | Riff Off Host | Film |
| 2013 | It's a Disaster | Glenn Randolph | Film |
| 2013 | Kung Fu Panda: The Awesome Secrets Collection | Crane (Voice) | Film |
| 2013 | The Arrested Development Documentary Project | Self | Film |
| 2013 | Kill Your Darlings | Louis Ginsberg | Film |
| 2012 | The Secret Policeman's Ball | Self | Film |
| 2011 | Alvin and the Chipmunks: Chipwrecked | Ian | Film |
| 2011 | Megamind: The Button of Doom | Minion (voice) | Film |
| 2011 | Fight for Your Right Revisited | Nathanial Hornblower | Film |
| 2011 | Demoted | Ken Castro | Film |
| 2011 | Kung Fu Panda 2 | Crane (voice) | Film |
| 2010 | The Legend of Secret Pass | Loo (voice) | Film |
| 2010 | David Cross: Bigger and Blackerer | Himself | Film |
| 2010 | Kung Fu Panda Holiday | Crane (voice) | Film |
| 2010 | Megamind | Minion (voice) | Film |
| 2010 | David Cross: Bigger and Blackerer | Writer | Film |
| 2009 | Year One | Cain | Film |
| 2009 | The Toe Tactic | Timmy (voice) | Film |
| 2009 | Important Things with Demetri Martin | Co-Worker | TV |
| 2009 | All Tomorrow's Parties | Self | Film |
| 2009 | Alvin and the Chipmunks: The Squeakquel | Ian | Film |
| 2008 | Kung Fu Panda: Secrets of the Furious Five | Crane (voice) | Film |
| 2008 | Futurama: The Beast with a Billion Backs | Yivo (voice) | Film |
| 2008 | Kung Fu Panda | Crane (voice) | Film |
| 2007 | Crashing | Space Station Man | Film |
| 2007 | The Comedians of Comedy: Live at The Troubadour | Self | Film |
| 2007 | Clark and Michael | Driving Instructor | TV |
| 2007 | Heckler | Self | Film |
| 2007 | The Grand | Larry Schwartzman | Film |
| 2007 | I'm Not There | Allen Ginsberg | Film |
| 2007 | Battle for Terra | Giddy (voice) | Film |
| 2007 | Fired! | Self | Film |
| 2007 | Alvin and the Chipmunks | Ian | Film |
| 2006 | Freak Show | Benny | TV |
| 2006 | Assume the Position with Mr. Wuhl | | Film |
| 2006 | School for Scoundrels | Ian | Film |
| 2006 | Curious George | Junior (voice) | TV |
| 2006 | She's the Man | Gold | Film |
| 2004 | Cheap Seats | Dr. Gail Timlin | TV |
| 2004 | Eternal Sunshine of the Spotless Mind | Rob | Film |
| 2003 | David Cross: Let America Laugh | Himself | Film |
| 2003 | Oliver Beene | Older Oliver Beene (voice) | TV |
| 2003 | Melvin Goes to Dinner | Seminar Leader | Film |
| 2003 | Arrested Development | Tobias Fünke | TV |
| 2003 | David Cross: Let America Laugh | Director | Film |
| 2002 | Run Ronnie Run | Ronnie Dobbs / Pootie T / Chow Chow | Film |
| 2002 | Martin & Orloff | | Film |
| 2002 | Life Without Dick | Rex | Film |
| 2002 | Men in Black II | Newton | Film |
| 2001 | Pootie Tang | Dennis | Film |
| 2001 | Scary Movie 2 | Dwight Hartman | Film |
| 2001 | Ghost World | Pushy Guy (Gerrold) | Film |
| 2001 | Night of the Living Doo | David Cross (voice) | Film |
| 2001 | One Day... | The Turd | Film |
| 2001 | Chain of Fools | Andy | Film |
| 1999 | David Cross: The Pride Is Back | Himself | Film |
| 1998 | Mr. Show and the Incredible, Fantastical News Report | Various Characters | Film |
| 1998 | Small Soldiers | Irwin Wayfair | Film |
| 1997 | Waiting for Guffman | UFO Expert | Film |
| 1997 | Who's the Caboose? | Jaded Guy | Film |
| 1997 | Men in Black | Morgue Attendant | Film |
| 1996 | The Truth About Cats & Dogs | Male Radio Caller (voice) / Bookstore Man | Film |
| 1996 | The Cable Guy | Sales Manager | Film |
| 1995 | Mr. Show with Bob and David | Self - Host / Various | TV |
| 1995 | Destiny Turns on the Radio | Ralph Dellaposa | Film |
| 1962 | The Creation of the Humanoids | Pax | Film |
| 1962 | The Magic Sword | Sir Pedro of Spain | Film |
| 1958 | The Decks Ran Red | Mace | Film |
| 1955 | The Night Holds Terror | Luther Logan | Film |