| 2025 | Captain America: Brave New World | President Thaddeus Ross | Film |
| 2023 | The Making of Indiana Jones and the Dial of Destiny | Self | Film |
| 2023 | Shrinking | Dr. Paul Rhodes | TV |
| 2023 | Indiana Jones and the Dial of Destiny | Indiana Jones | Film |
| 2022 | 1923 | Jacob Dutton | TV |
| 2020 | The Call of the Wild | John Thornton | Film |
| 2020 | The Skywalker Legacy | Self | Film |
| 2019 | The Secret Life of Pets 2 | Rooster (voice) | Film |
| 2019 | Alan Pakula: Going for Truth | Self | Film |
| 2017 | Blade Runner 2049 | Rick Deckard | Film |
| 2016 | Secrets of the Force Awakens: A Cinematic Journey | Self | Film |
| 2015 | Star Wars: The Force Awakens | Han Solo | Film |
| 2015 | The Age of Adaline | William Jones | Film |
| 2014 | The Expendables 3 | Max Drummer | Film |
| 2014 | The Doors - Feast of Friends: Encore | Himself | Film |
| 2013 | Warwick Davis and the Seven Dwarfs of Auschwitz | Self (archive footage, uncredited) | Film |
| 2013 | Anchorman 2: The Legend Continues | Mack Tannen | Film |
| 2013 | Milius | Self | Film |
| 2013 | Drew: The Man Behind the Poster | Self | Film |
| 2013 | Paranoia | Jock Goddard | Film |
| 2013 | Ender's Game | Colonel Hyrum Graff | Film |
| 2013 | 42 | Branch Rickey | Film |
| 2012 | Roman Polanski: A Film Memoir | Self (archive footage) | Film |
| 2012 | Final Cut: Ladies and Gentlemen | (archive footage) | Film |
| 2012 | Water to Wine | Jethro the Bus Driver | Film |
| 2011 | Cowboys & Aliens | Woodrow Dolarhyde | Film |
| 2011 | The Love We Make | Self | Film |
| 2010 | Morning Glory | Mike Pomeroy | Film |
| 2010 | Under the Boardwalk: The Monopoly Story | Jack Ryan (archive footage) | Film |
| 2010 | Extraordinary Measures | Dr. Robert Stonehill | Film |
| 2010 | Brace for Impact: The Chesley B. Sullenberger Story | Self - Narrator (voice) | Film |
| 2009 | Crossing Over | Max Brogan | Film |
| 2009 | What Remains of Honor | Laurent de Casteville | TV |
| 2008 | Lord of the Ants | Narrator | Film |
| 2008 | Indiana Jones and the Kingdom of the Crystal Skull | Indiana Jones | Film |
| 2007 | Dalai Lama Renaissance | Narrator | Film |
| 2007 | Dangerous Days: Making Blade Runner | Self | Film |
| 2006 | Firewall | Jack Stanfield | Film |
| 2004 | Empire of Dreams: The Story of the Star Wars Trilogy | Self | Film |
| 2003 | Late Night with Conan O'Brien: 10th Anniversary Special | Self | Film |
| 2003 | Indiana Jones: Making the Trilogy | self | Film |
| 2003 | Hollywood Homicide | Sgt. Joe Gavilan | Film |
| 2002 | K-19: The Widowmaker | Alexei Vostrikov | Film |
| 2001 | Lost Worlds: Life in the Balance | Narrator | Film |
| 2001 | R2-D2: Beneath the Dome | Self | Film |
| 2001 | On the Run with 'The Fugitive' | Self | Film |
| 2000 | What Lies Beneath | Norman Spencer | Film |
| 1999 | Random Hearts | Dutch Van Den Broeck | Film |
| 1998 | Six Days Seven Nights | Quinn Harris | Film |
| 1998 | Masters of the Martial Arts Presented by Wesley Snipes | Self (archive footage) | Film |
| 1997 | Air Force One | James Marshall | Film |
| 1997 | The Devil's Own | Tom O'Meara | Film |
| 1995 | Sabrina | Linus Larrabee | Film |
| 1995 | One Hundred and One Nights | Self | Film |
| 1995 | The World of Jacques Demy | Self | Film |
| 1994 | Clear and Present Danger | Jack Ryan | Film |
| 1994 | Jimmy Hollywood | Harrison Ford (uncredited) | Film |
| 1993 | The Fugitive | Richard Kimble | Film |
| 1992 | Patriot Games | Jack Ryan | Film |
| 1991 | Regarding Henry | Henry Turner | Film |
| 1990 | Presumed Innocent | Rusty Sabich | Film |
| 1989 | Indiana Jones and the Last Crusade | Indiana Jones | Film |
| 1988 | Frantic | Richard Walker | Film |
| 1988 | Working Girl | Jack Trainer | Film |
| 1986 | The Mosquito Coast | Allie Fox | Film |
| 1985 | Witness | John Book | Film |
| 1984 | Indiana Jones and the Temple of Doom | Indiana Jones | Film |
| 1983 | Return of the Jedi | Han Solo | Film |
| 1983 | From Star Wars to Jedi: The Making of a Saga | Self | Film |
| 1982 | Blade Runner | Deckard | Film |
| 1981 | Great Movie Stunts: Raiders of the Lost Ark | Self - Host | Film |
| 1981 | The Making of 'Raiders of the Lost Ark' | | Film |
| 1981 | Raiders of the Lost Ark | Indiana Jones | Film |
| 1980 | SP FX: The Empire Strikes Back | Han Solo (archive footage) | Film |
| 1980 | The Empire Strikes Back | Han Solo | Film |
| 1979 | The Frisco Kid | Tommy | Film |
| 1979 | Apocalypse Now | Colonel | Film |
| 1979 | Hanover Street | David Halloran | Film |
| 1978 | Force 10 from Navarone | Barnsby | Film |
| 1978 | The Star Wars Holiday Special | Han Solo | Film |