| 2026 | You Had to Be There: How the Toronto Godspell Ignited the Comedy Revolution... | Self / Jeffrey | Film |
| 2026 | Lorne | Self | Film |
| 2026 | Marty, Life Is Short | Self | Film |
| 2025 | John Candy: I Like Me | Self - Actor, SCTV | Film |
| 2025 | I'm Chevy Chase and You're Not | Self | Film |
| 2024 | Grimsburg | Otis Volcanowitz (voice) | TV |
| 2023 | Aquaman and the Lost Kingdom | Kingfish (voice) | Film |
| 2021 | Only Murders in the Building | Oliver Putnam | TV |
| 2021 | Only Murders in the Building | Executive Producer | TV |
| 2020 | The Willoughbys | The Father (voice) | Film |
| 2020 | Father of the Bride Part 3 (ish) | Franck Eggelhoffer | Film |
| 2019 | The Addams Family | Grandpa Frump (voice) | Film |
| 2018 | Steve Martin and Martin Short: An Evening You Will Forget for the Rest of Your Life | Self | Film |
| 2018 | Elliot: The Littlest Reindeer | Lemondrop / Ludzinka / Blitzen (voice) | Film |
| 2018 | Steve Martin and Martin Short: An Evening You Will Forget for the Rest of Your Life | Writer | Film |
| 2018 | Steve Martin and Martin Short: An Evening You Will Forget for the Rest of Your Life | Executive Producer | Film |
| 2017 | Night of Too Many Stars: America Unites for Autism Programs | Self | Film |
| 2016 | Hairspray Live! | Wilbur Turnblad | Film |
| 2016 | Match Game | Self - Host | TV |
| 2016 | Match Game | Executive Producer | TV |
| 2014 | Inherent Vice | Dr. Rudy Blatnoyd, D.D.S. | Film |
| 2014 | Legends of Oz: Dorothy's Return | The Appraiser / The Jester (voice) | Film |
| 2012 | Cat in the Hat: Ocean Commotion | | Film |
| 2012 | Madagascar 3: Europe's Most Wanted | Stefano (voice) | Film |
| 2012 | The Cat in the Hat Knows a Lot About Christmas! | The Cat in the Hat | Film |
| 2012 | Cat in the Hat: Miles & Miles of Reptiles | Cat in the Hat | Film |
| 2012 | Frankenweenie | Mr. Frankenstein / Mr. Burgemeister / Nassor (voice) | Film |
| 2011 | Cat in the Hat: Tricks and Treats | The Cat in the Hat | Film |
| 2011 | Cat in the Hat: Tales About Tails | The Cat in the Hat | Film |
| 2011 | Hoodwinked Too! Hood VS. Evil | Kirk the Woodsman (voice) | Film |
| 2010 | The Cat in the Hat Knows a Lot about That!: Wings and Things | The Cat in the Hat | Film |
| 2010 | The Cat in the Hat: Surprise, Little Guys! | The Cat in the Hat | Film |
| 2008 | The Spiderwick Chronicles | Thimbletack (voice) | Film |
| 2007 | O Canada! | Narrator | Film |
| 2006 | The Santa Clause 3: The Escape Clause | Jack Frost | Film |
| 2005 | Jiminy Glick in Lalawood | Jiminy Glick / David Lynch | Film |
| 2005 | Jiminy Glick in Lalawood | Writer | Film |
| 2005 | Jiminy Glick in Lalawood | Producer | Film |
| 2004 | Barbie as The Princess & the Pauper | Preminger (voice) | Film |
| 2003 | Saturday Night Live: 25 Years of Music Vol. 5 | Self | Film |
| 2003 | 101 Dalmatians II: Patch's London Adventure | Lars (voice) | Film |
| 2002 | Treasure Planet | B.E.N. (voice) | Film |
| 2001 | Jimmy Neutron: Boy Genius | Ooblar (voice) | Film |
| 2001 | Get Over It | Dr. Desmond Forrest Oates | Film |
| 2001 | Prince Charming | Rodney | Film |
| 1999 | Mumford | Lionel Dillard | Film |
| 1999 | Alice in Wonderland | Mad Hatter | Film |
| 1999 | The Martin Short Show | Self - Host | TV |
| 1998 | The Prince of Egypt | Huy (voice) | Film |
| 1997 | A Simple Wish | Murray | Film |
| 1997 | Jungle 2 Jungle | Richard Kempster | Film |
| 1996 | Mars Attacks! | Jerry Ross | Film |
| 1995 | Father of the Bride Part II | Franck Eggelhoffer | Film |
| 1995 | The Pebble and the Penguin | Hubie (voice) | Film |
| 1994 | Clifford | Clifford Daniels | Film |
| 1993 | We're Back! A Dinosaur's Story | Stubbs the Clown (voice) | Film |
| 1992 | A Spinal Tap Reunion: The 25th Anniversary London Sell-Out | Martin Short | Film |
| 1992 | Captain Ron | Martin Harvey | Film |
| 1991 | Pure Luck | Eugene Proctor | Film |
| 1991 | Father of the Bride | Franck Eggelhoffer | Film |
| 1989 | The Big Picture | Neil Sussman - Nick's Agent | Film |
| 1989 | Three Fugitives | Ned Perry | Film |
| 1989 | Dink, the Little Dinosaur | | TV |
| 1987 | Cross My Heart | David Morgan | Film |
| 1987 | Innerspace | Jack Putter | Film |
| 1986 | ¡Three Amigos! | Ned Nederlander | Film |
| 1985 | Martin Short: Concert for the North Americas | | Film |
| 1985 | Martin Short: Concert for the North Americas | Writer | Film |
| 1985 | Martin Short: Concert for the North Americas | Executive Producer | Film |
| 1979 | Lost and Found | Engel | Film |
| 1976 | Second City Television | Self - Various Characters | TV |