| 2025 | The SpongeBob Movie: Search for SquarePants | JK Fishlips (voice) | Film |
| 2024 | The Underdoggs | Coach Feis | Film |
| 2023 | Blue Beetle | Rudy Reyes | Film |
| 2021 | Christmas in Tahoe | Otis | Film |
| 2020 | Cats & Dogs 3: Paws Unite | Pablo the Parrot (voice) | Film |
| 2018 | Survivor's Guide to Prison | Self | Film |
| 2014 | Saint George | George | TV |
| 2014 | Rio 2 | Rafael (voice) | Film |
| 2014 | Saint George | Executive Producer | TV |
| 2013 | Richard Pryor: Omit the Logic | Self | Film |
| 2013 | Escape from Planet Earth | Thurman (voice) | Film |
| 2012 | Beverly Hills Chihuahua 3: Viva la Fiesta! | Papi (voice) | Film |
| 2012 | George Lopez: It's Not Me, It's You | Self | Film |
| 2012 | George Lopez: It's Not Me, It's You | Writer | Film |
| 2011 | The Smurfs: A Christmas Carol | Grouchy (voice) | Film |
| 2011 | Beverly Hills Chihuahua 2 | Papi (voice) | Film |
| 2011 | Rio | Rafael (voice) | Film |
| 2010 | Marmaduke | Carlos (voice) | Film |
| 2010 | Back From Hell: A Tribute to Sam Kinison | Self | Film |
| 2010 | The Spy Next Door | Glaze | Film |
| 2010 | Valentine's Day | Alphonso | Film |
| 2009 | Mr. Troop Mom | Eddie Serrano | Film |
| 2009 | George Lopez: Tall, Dark & Chicano | Himself | Film |
| 2009 | George Lopez: Tall, Dark & Chicano | Writer | Film |
| 2009 | George Lopez: Tall, Dark & Chicano | Executive Producer | Film |
| 2008 | Beverly Hills Chihuahua | Papi (voice) | Film |
| 2008 | Tortilla Heaven | Everardo | Film |
| 2008 | Henry Poole Is Here | Father Salizar | Film |
| 2008 | The Naked Brothers Band: Polar Bears | Self | Film |
| 2008 | Swing Vote | John Sweeney | Film |
| 2007 | George Lopez: America's Mexican | Himself | Film |
| 2007 | Brown Is the New Green: George Lopez and the American Dream | Himself | Film |
| 2007 | Balls of Fury | Agent Ernie Rodriquez | Film |
| 2007 | Balls Out: The Making of 'Balls of Fury' | | Film |
| 2007 | George Lopez: America's Mexican | Writer | Film |
| 2007 | George Lopez: America's Mexican | Executive Producer | Film |
| 2005 | George Lopez: Why You Crying? | Himself | Film |
| 2005 | The Adventures of Sharkboy and Lavagirl | Mr. Electricidad / Tobor / Ice Guardian | Film |
| 2005 | George Lopez: Why You Crying? | Writer | Film |
| 2005 | George Lopez: Why You Crying? | Executive Producer | Film |
| 2003 | Richard Pryor: I Ain't Dead Yet, #*%$#@!! | Self | Film |
| 2003 | Walt Disney World Christmas Day Parade | Self - Host | Film |
| 2002 | Real Women Have Curves | Mr. Guzman | Film |
| 2002 | The Original Latin Kings of Comedy | Himself | Film |
| 2002 | Outta Time | Felix | Film |
| 2002 | The Original Latin Kings of Comedy | Writer | Film |
| 2000 | Bread and Roses | Perez | Film |
| 1993 | Fatal Instinct | Murder Investigator | Film |
| 1990 | Ski Patrol | Eddie Martinez | Film |